Rahadian Zainul; Dony Novaliendry; Agariadne Dwinggo Samala; Budhi Oktavia; Cheng-Hong Yang; Devi Purnamasari; Mirella Fonda Maahury; Rollando Rollando; Rismi Verawati; Muhammad Arya Ghifari; Muhammad Thoriq Albari; Muhammmad Raffi Ghifari; Putri Azhari; Riso Sari Mandeli
Abstract
This research aims to study the interaction between astragaloside, astragalus plant extract, and adrenergic receptor alpha-2 as a regulation of sympathetic nervous system activity. ...
Read More
This research aims to study the interaction between astragaloside, astragalus plant extract, and adrenergic receptor alpha-2 as a regulation of sympathetic nervous system activity. The research methods used include the use of Pymol, Pyrex, Protein Plus, and Lipinski Rule software for molecular analysis and protein structure characterization. The results showed that astragaloside had a binding affinity of -6.4. In addition, RMSD was found to be 0, 2.515, and 2.703, which indicated the success of astragaloside in interacting with adrenergic receptor alpha-2. Analysis using Protein Plus showed an interaction between astragaloside and adrenergic receptor alpha-2. Lipinski analysis showed that astragaloside has a mass of 618, 10 hydrogen bond donors, 17 hydrogen bond recipients, a logP of -0.0197, and a molar reactivity of 127.710. These findings provide further understanding of the mechanism of astragaloside's interaction with adrenergic receptor alpha-2, which could potentially regulate sympathetic nervous system activity. This study contributes to the therapies development based on astragalus plant extracts for effective regulation of sympathetic nervous system function.
